PTD-DBM 1mg (peptide action as a hair growth stimulant)
Form: lyophilizate 1mg
Androgenetic alopecia is the most common type of hair loss in both men and women. Baldness occurs in a large percentage of adults and progresses with age. Thus, the incidence of alopecia in men aged 40–55 years is 31% and reaches 53% in 65–69 years. Androgenetic alopecia is not only a cosmetic defect, but a serious problem, as it can cause psychological stress, anxiety, low self-esteem and depression. The 5α-reductase inhibitor finasteride and the topical vasodilator minoxidil are the only FDA-approved treatments for alopecia, but their use is limited by low efficacy and potentially unwanted side effects. In this regard, the development of new anti-baldness drugs with a more attractive biological profile remains relevant.
PTD-DBM was developed and patented as a follicle regeneration agent in 2014 by a group of researchers led by Prof. Choi Kang-yeol at Yonsei University (Seoul, South Korea). Scientists have discovered a protein responsible for hair loss in androgenetic alopecia. This protein controls hair growth, and a new substance, acting with it, modulates the function and promotes hair regeneration. This polypeptide is called CXXC5 - CXXC-type zinc finger protein 5, which acts as a negative regulator of the Wnt/β-catenin signaling pathway, which is associated with hair regeneration and wound healing. CXXC5 binds to the Disheveled protein and prevents follicle development and hair regrowth. This pathway has been shown to promote DHT-induced miniaturization of hair follicles. This knowledge has led to the development of a new biochemical, PTD-DBM, which interferes with this binding process. Many researchers believe that intracellular Wnt signaling pathways are responsible for hair follicle development and hair regeneration in humans.
There are three components of a possible approach for the treatment of alopecia. Microneedle wounds stimulate follicle formation, valproic acid activates a cellular pathway associated with follicle development, and the PTD-DBM peptide prevents the CXXC5 protein from negatively interfering with follicle development. Studies have shown that PTD-DBM is significantly more effective in stimulating hair regeneration when combined with valproic acid when applied topically. This combination is best used after exposure to the microneedles to take advantage of their effect on follicle development. In addition, further study of WIHN will reveal key stages in mammalian development and regeneration, which may lead to new clinical treatments for wounds and alopecia. The PTD-DBM peptide and valproic acid are available online in aerosol cans and are recommended by the manufacturers for daily application to the scalp; Dermarollers with microneedles are usually used 1-2 times a week. However, potential users should be wary of this information as the method has not yet received official regulatory approval.
Quantity: 1 mg
Purity: over 97%
Storage: no more than +5C
Amino acid sequence: Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Gly-Gly-Gly-Arg-Lys-Thr-Gly-His-Gln-Ile-Cys-Lys-Phe-Arg-Lys-Cys
Molecular weight: 3082.68
Molecular formula: C124H225N61O28S2
Synonyms: Protein transduction domain-Dvl-binding motif, PTD-Dvl-binding motif, PolyR8-HFAP, RRRRRRRRGGGGRKTGHQICKFRKC
Main area of research: wound healing agent, hair growth stimulant
Peptides, proteins, enzymes and hormones produced in the human body have attracted the attention of researchers since their discovery due to their biological properties, potentially useful in pharmacology. Due to their natural origin and unique structure, these compounds are a priori highly active and toxicity is low or absent. It is natural that many such regulatory molecules and their derivatives are introduced into medical practice, and also serve as the basis for the development of synthetic drugs with similar or even improved properties, but much more accessible for large-scale production compared to natural substances.
Method of application:
Peptide substances are being introduced into our lives very actively. The main achievements in medicine, pharmacology, nanotechnology, cosmetology, dentistry, veterinary medicine, agriculture, food and other industries are associated with them.
Peptides are widely used due to the possibility of modeling their structure, high biological activity, minimal toxic and side effects, both directed and systemic action, high bioavailability, biodegradability and environmental friendliness, good solubility and low therapeutic dose. It is important to have efficient methods for the rapid synthesis of peptides to order with a high degree of purification. Knowledge of the features of physical properties allows you to isolate natural peptide and protein molecules from plant and animal raw materials.
Guaranteed authenticity and quality:
100% original product from RUSSIAN PEPTIDE (Russian Federation)
RUSSIAN PEPTIDE is an innovative technology-driven R&D enterprise providing a full range of services to the pharmaceutical, biotechnology and cosmetics industries. The main goal of the company is to promote science, research and development, develop technology, expand the scope of innovative products for health, improve the quality of life, safety and environmental protection.
Development and production:
RUSSIAN PEPTIDE (Russian Federation)
The company specializes in the development of technology and production of peptides and complex organic molecules as biologically active ingredients and their intermediates, biochemical substances for in vitro research purposes.
The company's arsenal includes original know-how technologies in peptide chemistry and fine organic synthesis. Well-established technological processes make it possible to produce peptide substances from small quantities, for testing, to industrial volumes.