DERINAT 0.25% (immunomodulating agent in solution spray bottle)

DERINAT® is an immunomodulator that selectively stimulates Toll-like receptors 9 (TLR9). TLR9 are located on macrophages, dendritic cells of any localization, B-lymphocytes. The study of the nucleotide composition of the terminal sections of the DNA fragments that are part of the preparation DERINAT® showed that the fragments end in an unmethylated CpG dinucleotide motif. Unmethylated CpG DNA motifs are specific ligands for TLR9.

Natrium deoxyribonucleat.

Solution for outward and local application.

Composition:

Active ingredient - natrium deoxyribonucleat 2.5 g

Auxiliary ingredients: natrium chloride 0,1 g, water for injection – 1000 ml. Transparent colorless liquid without any inclusions.

Immunomodulating preparation, regenerant, reparant.

The preparation activates the processes of innate and adaptive immunities. It optimizes specific responses to fungal, viral, and bacterial infections. The preparation stimulates reparative and regenerative processes, normalizes a tissues and organs condition. Derinat contributes to the cicatrization of trophic ulcers of various aetiologies. It also contributes to quick recovery of full-thickness burns. Derinat prevents scarring of mucosal in the healing of ulcers. The preparation has neither teratogenic nor carcinogenic action.

When applied locally, Derinat is absorbed fast and distributed within organs and tissues via endolymphatic transportation way. At the phase of the intensive preparation absorption into blood, plasma and blood cells, the preparation are redistributed simultaneously with metabolism and excretion. It is excreted from organism (as metabolites), mainly with urine and partially with faeces. Excretion of the preparation from the body is described by a bi-exponential graph.

Indications:

• ARD (acute respiratory disease) – monotherapy;
• ARVI (acute respiratory viral infection) – monotherapy;
• rhinitis;
• sinuitis, antritis, frontal sinusitis;
• obliterating diseases of leg
• trophic ulcers;
• chronic nonhealing and infected wounds (including diabetic ones)
• gangrene;
• burns;
• chilblains;
• oral, eye, nasal, vaginal and rectal inflammatory diseases;
• haemorrhoids.

Dosage and administration:

The preparation is prescribed for children from the first day of life and adults.

For the prevention of SARS, 2 drops are instilled into the nose or 1 spray into each nasal passage 2-4 times a day for 1-2 weeks.

For acute respiratory infections, acute respiratory viral infections, the preparation is instilled into the nose 2-3 drops in each nasal passage or 1-2 sprays in each nasal passage every 1-1.5 hours, during the first day; then - 2-3 drops or 1 spray in each nasal passage 3-4 times a day, course duration - 1 month.

In case of inflammatory diseases of the nasal cavity and paranasal sinuses, the preparation is instilled 3-5 drops or 1-2 sprays into each nasal passage 4-6 times a day. Course duration - 7-15 days.

In case of diseases of the oral mucosa, the preparation is rinsed 4-6 times a day (1 bottle - 1-2 rinses) or the preparation is evenly sprayed onto the corresponding damaged areas of the mucosa, 2-3 sprays 4-6 times a day. The duration of the course of therapy is 5-10 days.

In chronic inflammatory diseases, fungal, bacterial and other infections in gynecology - intravaginal administration with irrigation of the cervix or intravaginal administration of tampons with the preparation, 5 ml per procedure, 1-2 times a day for 10-14 days.

With hemorrhoids, the preparation is prescribed in the form of microclysters in the rectum, 15-40 ml each. The duration of the course of therapy is 4-10 days.

In case of obliterating diseases of the lower extremities, the preparation is instilled into the nose along
1-2 drops in each nasal passage 6 times a day, the duration of the course is up to 6 months.

With post-radiation necrosis of the skin and mucous membranes, with long-term non-healing wounds, burns, frostbite, trophic ulcers of various etiologies, gangrene, application dressings (two layers of gauze) are applied to the affected areas with the preparation applied 3-4 times a day or treated the affected surface with the preparation from the sprayer 4-5 times a day, 10-40 ml (therapy course - 1-3 months).

Release form:

Solution for local and external use 0.25%.  10 ml in colorless or brown glass bottles, sealed with horizontal or vertical spray nozzles, equipped with protective caps. 

Best before date:

5 years. Do not use after the expiry date stated on the packaging. Use the contents of the opened vial within two weeks.

Storage conditions:

In a place protected from light at a temperature not exceeding 25 ° C. Keep out of the reach of children.

Guaranteed authenticity and quality:

100% Original from PHARM PACK (Russian Federation)

Development and production:

PHARM PACK (Russian Federation)